In vivo photoacoustic monitoring of anti-obesity photothermal lipolysis

Donghyun Lee; Jung Ho Lee; Sei Kwang Hahn; Chulhong Kim

doi:10.1117/12.2288906

19 February 2018 In vivo photoacoustic monitoring of anti-obesity photothermal lipolysis

Donghyun Lee, Jung Ho Lee, Sei Kwang Hahn, Chulhong Kim

Author Affiliations +

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 1049460 (2018) https://doi.org/10.1117/12.2288906
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Obesity with a body mass index is greater than 30 kg/m² is one of the rapidly growing diseases in advanced societies and can lead to stroke, type 2 diabetes, and heart failure. Common methods of removing subcutaneous adipose tissues are liposuction and laser treatment. In this study, we used photoacoustic imaging to monitor the anti-obesity photothermal degradation process. To improve the photothermal lipid degradation efficiency without any invasive methods, we synthesized hyaluronic acid hollow hold nanosphere adipocyte targeting sequence peptide (HA-HAuNS-ATS) conjugates. The conjugate enhanced the skin penetration ability and biodegradability of the nanoparticles using hyaluronate and enhanced the targeting effect on adipose tissue with adipocyte targeting sequence peptide. Thus, the conjugate can be delivered to the adipose tissue by simply spreading the conjugate on the skin without any invasive method. Then, the photothermal lipolysis and delivery of the conjugate were photoacoustically monitored in vivo. These results demonstrate the potential for photoacoustic method to be applied for photothermal lipolysis monitoring.

Citation Download Citation

Donghyun Lee, Jung Ho Lee, Sei Kwang Hahn, and Chulhong Kim "In vivo photoacoustic monitoring of anti-obesity photothermal lipolysis", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 1049460 (19 February 2018); https://doi.org/10.1117/12.2288906

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