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19 February 2018 The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy
Sean M. Laverty, Bryan A. Dawkins, Wei R. Chen
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Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 1049510 (2018) https://doi.org/10.1117/12.2291694
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
We extend our model of the antitumor immune response initiated by laser-immunotherapy treatment to more closely examine key steps in the immune response 1) tumor antigen acquisition by antigen-presenting dendritic cells (DCs) and 2) cytotoxic T cell (CTL) priming by lymphatic DCs. Specifically we explore the formation of DC-CTL complexes that lead to CTL priming. We find that the bias in the dissociation rate of the complex influences the outcome of treatment. In particular, a bias towards priming favors a rapid activated CTL response and the clearance of tumors.
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Sean M. Laverty, Bryan A. Dawkins, and Wei R. Chen "The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 1049510 (19 February 2018); https://doi.org/10.1117/12.2291694
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KEYWORDS
Mathematical modeling
Mathematics
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