The Preparation And Application Of Porphyrin-Monoclonal Antibodies For Cancer Therapy

Kevin J. Steele; Daniel Liu; Noelle Davis; Heather Deal; Julia G. Levy

doi:10.1117/12.978006

13 June 1989 The Preparation And Application Of Porphyrin-Monoclonal Antibodies For Cancer Therapy

Kevin J. Steele, Daniel Liu, Noelle Davis, Heather Deal, Julia G. Levy

Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.978006
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

Monoclonal antibodies with reactivity to T suppressor cells and T suppressor factors, conjugated to hematoporphyrin, when injected intravenously into mice bearing either the P815 mastocytoma or L1210 thymoma were able to reject a significant number of palpable tumors, in comparison to appropriate controls. This effect is attributed to immune modulation by selective elimination of T suppressor cells. Investigation of novel methodology for reliable linkage of photosensitizers to antibodies indicate that derivatives of polyvinyl alcohol provide suitable carriers for photosensitizers. Such carriers can relatively easily be conjugated to monoclonal antibodies without jeopardizing the biological activity of the antibody or the photosensitizer, or the solubility of the complex.

Citation Download Citation

Kevin J. Steele, Daniel Liu, Noelle Davis, Heather Deal, and Julia G. Levy "The Preparation And Application Of Porphyrin-Monoclonal Antibodies For Cancer Therapy", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); https://doi.org/10.1117/12.978006

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