Simulation of the dose control for vascular targeted photodynamic therapy

Yan Mo; Xiaoming Hu; Jixia Zhang

doi:10.1117/12.2501023

23 October 2018 Simulation of the dose control for vascular targeted photodynamic therapy

Yan Mo, Xiaoming Hu, Jixia Zhang

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 108202H (2018) https://doi.org/10.1117/12.2501023
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Dose control is one of the key factors of clinical treatment for port wine stains (PWS) under vasculature-targeted photodynamic therapy. A skin simulation model was proposed to show the PDT Type II reaction around the microcapillaries, and to establish the optimal PDT protocol such as light modulation for different PWS vascular types. A simplified two-dimensional cross section of PWS vascular composed of a single superficial epidermal layer, a deeper dermal layer, and a microcapillaries was used. A series of capillary diameters of 40, 70, 100 and 130 micrometers were used to model typical PWS lesions with different blood flow rates. Oxygen and photosensitizers (PS) are pumped from the microartery at heartbeat frequency and exit the vasculature from the microvein, and a PDT type II reaction occurs near the vessel wall: PS excited by light absorption combines with free oxygen, which leads to a reactive singlet state of oxygen (SSO) that in turn causes direct endothelial cell damage. The mathematical simulation model equations are composed of light transmission, oxygen diffusion, photosensitizer diffusion, singlet oxygen generation and photobleaching, which were solved by finite element method. With the drug diffusion and optical absorption properties of human skin, the photon consumption, drugs and oxygen diffusion and photochemical processes within the vessel wall can be simulated. This simulation can provide a quantitative method to optimize the light and drug dose for clinical treatment of PWS.

Citation Download Citation

Yan Mo, Xiaoming Hu, and Jixia Zhang "Simulation of the dose control for vascular targeted photodynamic therapy", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108202H (23 October 2018); https://doi.org/10.1117/12.2501023

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
14 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Oxygen

Photodynamic therapy

Picosecond phenomena

Blood circulation

Modulation

Blood vessels

Diffusion

Show All Keywords

Keywords/Phrases

Search In:

Publication Years