Uptake of a fluorescence imaging agent in an orthotopic glioblastoma using fluorescence molecular tomography

Negar Sadeghipour; Boyu Meng; Margaret R. Folaron; Rendall R. Strawbridge; Kimberley S. Samkoe; Kenneth M. Tichauer; Scott C. Davis

doi:10.1117/12.2510904

7 March 2019 Uptake of a fluorescence imaging agent in an orthotopic glioblastoma using fluorescence molecular tomography

Negar Sadeghipour, Boyu Meng, Margaret R. Folaron, Rendall R. Strawbridge, Kimberley S. Samkoe, Kenneth M. Tichauer, Scott C. Davis

Author Affiliations +

Proceedings Volume 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V; 108620J (2019) https://doi.org/10.1117/12.2510904
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We reported the uptake value of a near-infrared imaging agent in an orthotopic glioma mouse models. The imaging agent was IRDy680®. The mice were injected with a trace amount of this imaging agent and imaged on a magnetic resonance imaging device that is coupled with a fluorescence imaging tomography system. By applying a reconstruction method, at each time point, we got a single value for the uptake of this imaging agent in the tumor region. The mean of the uptake values in the mice is reported here.

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Negar Sadeghipour, Boyu Meng, Margaret R. Folaron, Rendall R. Strawbridge, Kimberley S. Samkoe, Kenneth M. Tichauer, and Scott C. Davis "Uptake of a fluorescence imaging agent in an orthotopic glioblastoma using fluorescence molecular tomography", Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108620J (7 March 2019); https://doi.org/10.1117/12.2510904

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