Phantom verification for lock-in-photon-counting-based diffuse optical tomography system

Xiangdong He; Jinbin Xie; Wenwen Du; Guoyan Yin; Han Liu; Jiao Li; Zhongxing Zhou; Feng Gao; Limin Zhang

doi:10.1117/12.2507416

1 March 2019 Phantom verification for lock-in-photon-counting-based diffuse optical tomography system

Xiangdong He, Jinbin Xie, Wenwen Du, Guoyan Yin, Han Liu, Jiao Li, Zhongxing Zhou, Feng Gao, Limin Zhang

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108741W (2019) https://doi.org/10.1117/12.2507416
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Diffuse optical tomography (DOT) is a novel functional imaging technique that has the vital clinical application. Aiming at the problems in DOT technology, we developed a three-wavelength continuous wave DOT system with high sensitivity and temporal resolution by adopting photo-multiple tube and photon counting detection, as well as lock-in technique. To assess the performance of the system, we conducted a series of cylindrical phantom experiments with optical properties that closely match those of human tissue, and obtained the reconstruction images by combining with our developed imaging scheme. The experimental results show that the position and size of the reconstructed targets are accurate, demonstrating the feasibility of the system. Additionally, the sensitivity, quantitativeness and spatial resolution of the imaging system were assessed by varying the target-to-background contrasting absorption contrast and target size. These preliminary results indicate that the system is scientifically capable of subcentimeter resolution imaging of low-contrast the lesion from the normal background.

Citation Download Citation

Xiangdong He, Jinbin Xie, Wenwen Du, Guoyan Yin, Han Liu, Jiao Li, Zhongxing Zhou, Feng Gao, and Limin Zhang "Phantom verification for lock-in-photon-counting-based diffuse optical tomography system", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741W (1 March 2019); https://doi.org/10.1117/12.2507416

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KEYWORDS

Imaging systems

Target recognition

Diffuse optical tomography

Spatial resolution

Optical properties

Photon counting

Tissue optics

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