Fiber optoacoustic converter for spatially confined ultrasound neuromodulation  (Conference Presentation)

Ying Jiang; Lu Lan; Hua-an Tseng; Cheng Yang; Hengye Man; Xue Han; Ji-Xin Cheng

doi:10.1117/12.2508752

4 March 2019 Fiber optoacoustic converter for spatially confined ultrasound neuromodulation (Conference Presentation)

Ying Jiang, Lu Lan, Hua-an Tseng, Cheng Yang, Hengye Man, Xue Han, Ji-Xin Cheng

Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 108780K (2019) https://doi.org/10.1117/12.2508752
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Generation of ultrasound using the optoacoustic effect has received increasing attention in the field of imaging and translational medicine. However, none of the current optoacoustic converters has been used for neural modulation. Here, we developed a miniaturized Fiber-Optoacoustic Converter (FOC), which has a diameter of 600 μm, and can convert nano-second laser pulses into acoustic waves through the optoacoustic effect. The ball shaped FOC is composed of one ZnO /epoxy based diffusion layer and two graphite/epoxy based absorption layer. The radiofrequency spectrum of the generated US frequency ranges from 0.1-5 MHz, with multiple frequencies peaks at 0.5, 1 and 3MHz. Compared to traditional ultrasound transducers, the FOC system has the advantages of miniaturized size, superior spatial resolution, and produces omnidirectional propagating acoustic wave. Using this FOC system, we show that ultrasound can directly activate individual cortical neuron in vitro with a radius of 500 μm around the FOC tip, and generate intracellular Ca2+ transient without neural damage. Neural activation is the consequence of mechanical disturbance of neuronal membrane, rather than direct laser or photothermal stimulation. Finally, we combine FOC neural modulation with electrophysiology, and achieve direct and spatially confined neural stimulation in vivo. The FOC system opens new possibilities to use optoacoustic effect as a new method for precise neural modulation.

Conference Presentation

Citation Download Citation

Ying Jiang, Lu Lan, Hua-an Tseng, Cheng Yang, Hengye Man, Xue Han, and Ji-Xin Cheng "Fiber optoacoustic converter for spatially confined ultrasound neuromodulation (Conference Presentation)", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108780K (4 March 2019); https://doi.org/10.1117/12.2508752

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical fiber cables

Ultrasonography

Optoacoustics

Modulation

Acoustics

Diffusion

Epoxies

Show All Keywords

Keywords/Phrases

Search In:

Publication Years