Multifocal photoacoustic microscopy through an ergodic relay (Conference Presentation)

Yang Li; Terence T. W. Wong; Junhui Shi; Hsun-Chia Hsu; Lihong V. Wang

doi:10.1117/12.2513502

4 March 2019 Multifocal photoacoustic microscopy through an ergodic relay (Conference Presentation)

Yang Li, Terence T. W. Wong, Junhui Shi, Hsun-Chia Hsu, Lihong V. Wang

Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 108781C (2019) https://doi.org/10.1117/12.2513502
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

To date, most optical-resolution photoacoustic microscopy (OR-PAM) systems rely on mechanical scanning with confocally aligned optical excitation and ultrasonic detection. As a result, the imaging speed of these systems is limited by the scanning speed. Although several multifocal OR-PA computed tomography (MFOR-PACT) systems had been developed to address this limitation, they were hindered by the complex design in a constrained physical space. Here, we present a two-dimensional (2D) MFOR-PAM system based on a 2D microlens array and an acoustic ergodic relay. This system is able to detect PA signals generated from 400 optical foci in parallel with a single-element transducer, and then raster scan the optical foci patterns to form an image. This system has improved the imaging resolution of a conventional photoacoustic ergodic relay system from 220 μm to 13 μm. Moreover, this system has reduced the imaging time of a conventional OR-PAM system at the same resolution and laser repetition rate by 400 times. We demonstrated the ability of the system with both in vitro and in vivo experiments.

Conference Presentation

Citation Download Citation

Yang Li, Terence T. W. Wong, Junhui Shi, Hsun-Chia Hsu, and Lihong V. Wang "Multifocal photoacoustic microscopy through an ergodic relay (Conference Presentation)", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108781C (4 March 2019); https://doi.org/10.1117/12.2513502

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