A speckle interferometric technique for the evaluation of corneal biomechanics under physiological pressure variations 
 (Conference Presentation)

Abby Wilson; John Marshall

doi:10.1117/12.2507660

13 March 2019 A speckle interferometric technique for the evaluation of corneal biomechanics under physiological pressure variations (Conference Presentation)

Abby Wilson, John Marshall

Author Affiliations +

Proceedings Volume 10880, Optical Elastography and Tissue Biomechanics VI; 108800Z (2019) https://doi.org/10.1117/12.2507660
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Clinical assessment of corneal biomechanics currently relies on evaluation of the response of a cornea to an air-puff directed at its centre. Despite this method showing potential for identifying the presence of biomechanical abnormalities, it cannot be used to quantify corneal biomechanical properties and it provides limited spatial information. There is currently widespread interest in the development of techniques capable of spatially mapping corneal biomechanics, as access to this information could not only accelerate the diagnosis and enhance the treatment of keratoconus, through enabling customised and individualised treatment protocols; it could also permit technologies such as corneal crosslinking to be optimised to offer a minimally-invasive alternative to refractive surgery, lowering the risk of complications, such as corneal ectasia, associated with current procedures. Here we present a method, using speckle interferometric techniques, to measure the full-field displacement of the cornea in response to intra-ocular pressure changes equivalent to those that occur during the cardiac cycle, over a measurement time of several milliseconds. To demonstrate its effectiveness for biomechanical assessment, ex vivo measurements were performed for 40 porcine corneas and 6 human corneas before and after crosslinking in isolated topographic regions. Prior to crosslinking, all corneas demonstrated significant regional variability in response to loading. Regional reductions in displacement of between 16 % to 80 % were observed after crosslinking dependent upon treatment location. These initial data demonstrate both the necessity for full-field evaluation of biomechanics and the potential for crosslinking to be used to alter the refractive power of the eye.

Conference Presentation

Citation Download Citation

Abby Wilson and John Marshall "A speckle interferometric technique for the evaluation of corneal biomechanics under physiological pressure variations (Conference Presentation)", Proc. SPIE 10880, Optical Elastography and Tissue Biomechanics VI, 108800Z (13 March 2019); https://doi.org/10.1117/12.2507660

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