When Na modulates Ca: nonlinear interplay between  Na/Ca-exchanger and  IP3-mediated Ca oscillations in astrocytes

Darya V. Verveyko; Andrey Yu. Verisokin; Dmitry E. Postnov; Alexey R. Brazhe

doi:10.1117/12.2523315

3 June 2019 When Na modulates Ca: nonlinear interplay between Na/Ca-exchanger and IP3-mediated Ca oscillations in astrocytes

Darya V. Verveyko, Andrey Yu. Verisokin, Dmitry E. Postnov, Alexey R. Brazhe

Author Affiliations +

Proceedings Volume 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 110670J (2019) https://doi.org/10.1117/12.2523315
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

We present a composite model of astrocytic Ca²⁺ dynamics, which includes both IP₃-mediated release from intracellular Ca²⁺ stores and bidirectional exchange through the plasma membrane, mediated by the Na⁺/Ca²⁺- exchanger (NCX). The NCX kinetic model is formulated in the Hodgkin/Huxley formalism, taking into account the glutamate transporter-mediated increase in Na+ during synaptic activity and Na⁺- and Ca²⁺-dependent regulation. We define main dynamic regimes and transitions in a point model, describing dynamics in an individual astrocyte segment. We demonstrate NCX-based modulation of store-mediated calcium oscillations (amplitude, frequency and amplitude-frequency), analyze and compare calcium dynamics in models with and without allosteric regulation of NCX by intracellular ions.

Citation Download Citation

Darya V. Verveyko, Andrey Yu. Verisokin, Dmitry E. Postnov, and Alexey R. Brazhe "When Na modulates Ca: nonlinear interplay between Na/Ca-exchanger and IP3-mediated Ca oscillations in astrocytes", Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 110670J (3 June 2019); https://doi.org/10.1117/12.2523315

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