Dosimetry recommendations for NMIBC: a simulation and in vivo study (Conference Presentation)

Lothar D. Lilge; Daniel Molehuis; Angelica Manalac; Fynn Schwiegelshohn; Vaughn Betz; Wayne Embree; Arkady Mandel; Roger Dumont-White; Girish Kulkani; Michael Jewett

doi:10.1117/12.2526079

14 August 2019 Dosimetry recommendations for NMIBC: a simulation and in vivo study (Conference Presentation)

Lothar D. Lilge, Daniel Molehuis, Angelica Manalac, Fynn Schwiegelshohn, Vaughn Betz, Wayne Embree, Arkady Mandel, Roger Dumont-White, Girish Kulkani, Michael Jewett

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110704S (2019) https://doi.org/10.1117/12.2526079
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Recurrent Non-Muscle Invasive Bladder Cancer (NMIBC) is a diffuse disease, and patients have failed standard BCG therapy face prophylactic cystectomy. PDT fell out of favour due to its variable outcome, and high morbidity. To overcome PDT associate toxicity to the bladder’s muscle layer, the use of shorter wavelength and instillation of the photosensitizer were suggested. While either approach was shown to improve the outcome in animal models they have not previously combined in human studies. Additionally, the effects of highly variable tissue optical properties of the bladder and its shape have not been studied. Here, we present surface dose histograms derived from light propagation simulation in 6 human bladders using CT images for anatomical detail and the FullMonte software package. The ability of a single light sensor versus 3 or 12 light sensors to measure the average irradiance on the bladder surface was evaluated as a function of the bladder wall’s tissue optical properties. Results show that the irradiance in non-spherical bladders can vary over an order of magnitude, but the irradiance histograms are affected little by displacement of the emitter inside the bladder void. As the surface area monitored by a single sensor depends strongly on the bladder shape, the responsivity of a single sensor to the average bladder irradiance can vary equally. Twelve light sensors monitor the entire bladder surface almost complete and hence their average responsivity is constant to the average irradiance on the bladder largely independent of shape. The dependency of the sensor’s response on the tissue optical properties is also lower.

Conference Presentation

Citation Download Citation

Lothar D. Lilge, Daniel Molehuis, Angelica Manalac, Fynn Schwiegelshohn, Vaughn Betz, Wayne Embree, Arkady Mandel, Roger Dumont-White, Girish Kulkani, and Michael Jewett "Dosimetry recommendations for NMIBC: a simulation and in vivo study (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110704S (14 August 2019); https://doi.org/10.1117/12.2526079

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Bladder

In vivo imaging

Natural surfaces

Optical properties

Optical sensors

Sensors

Tissue optics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years