Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images

Masanori Takabayashi; Hassaan Majeed; Andre Kajdacsy-Balla; Gabriel Popescu

doi:10.1117/12.2538728

19 November 2019 Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images

Masanori Takabayashi, Hassaan Majeed, Andre Kajdacsy-Balla, Gabriel Popescu

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Proceedings Volume 11185, Optical Design and Testing IX; 111850B (2019) https://doi.org/10.1117/12.2538728
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

The intrinsic markers of nanoscale morphological alteration in fixed tissue biopsy referred to as disorder strength and local correlation length, which can be easily and time-efficiently obtained from quantitative phase images, are introduced. After presenting how to extract these markers from quantitative phase images obtained by highly sensitive quantitative phase imaging system, spatial light interference microscopy (SLIM), we demonstrate the effectiveness of these markers for diagnosis of benign and malignant breast tissues.

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Masanori Takabayashi, Hassaan Majeed, Andre Kajdacsy-Balla, and Gabriel Popescu "Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images", Proc. SPIE 11185, Optical Design and Testing IX, 111850B (19 November 2019); https://doi.org/10.1117/12.2538728

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