Towards an active micropump-mixer for rapid anti-platelet drug screening in whole blood

Crispin Szydzik; Rose J. Brazilek; Farzan Akbaridoust; Charitha de Silva; Mitchell Moon; Ivan Marusic; Harshal H. Nandurkar; Justin R. Hamilton; Arnan Mitchell; Warwick S. Nesbitt

doi:10.1117/12.2541102

31 December 2019 Towards an active micropump-mixer for rapid anti-platelet drug screening in whole blood

Crispin Szydzik, Rose J. Brazilek, Farzan Akbaridoust, Charitha de Silva, Mitchell Moon, Ivan Marusic, Harshal H. Nandurkar, Justin R. Hamilton, Arnan Mitchell, Warwick S. Nesbitt

Author Affiliations +

Proceedings Volume 11201, SPIE Micro + Nano Materials, Devices, and Applications 2019; 1120116 (2019) https://doi.org/10.1117/12.2541102
Event: ANZCOP, 2019, Melbourne, Australia

Abstract

This work reports on development and characterization of an on-chip microfluidic handling system for application in preclinical anti-platelet drug screening. A reciprocating elastomeric micropump/mixer design is presented for use with whole human blood, utilizing flexible structural and actuation properties to manage hemodynamics for an on-chip platelet thrombosis assay on fibrillar collagen. The hemocompatibility of the design is assessed across a range of operational configurations, demonstrating equivalent or superior performance to common microcapillary systems at a range of physiologically relevant shear conditions. Surprisingly efficient mixing phenomena are briefly investigated, validated using dyes within the molecular weight range of common antiplatelet therapies. Finally, a proof-of-concept preclinical application is explored, demonstrating that this prototype can act as a real-time assay of anti-platelet drug pharmacokinetics, compared to an equivalent microcapillary system.

Citation Download Citation

Crispin Szydzik, Rose J. Brazilek, Farzan Akbaridoust, Charitha de Silva, Mitchell Moon, Ivan Marusic, Harshal H. Nandurkar, Justin R. Hamilton, Arnan Mitchell, and Warwick S. Nesbitt "Towards an active micropump-mixer for rapid anti-platelet drug screening in whole blood", Proc. SPIE 11201, SPIE Micro + Nano Materials, Devices, and Applications 2019, 1120116 (31 December 2019); https://doi.org/10.1117/12.2541102

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