Optimizing selective phototherapy of port wine stain by two-photon fluorescence and optical coherence tomography imaging (Conference Presentation)

Iván Coto Hernández; Nate Jowett; Tan Oon

doi:10.1117/12.2545320

6 March 2020 Optimizing selective phototherapy of port wine stain by two-photon fluorescence and optical coherence tomography imaging (Conference Presentation)

Iván Coto Hernández, Nate Jowett, Tan Oon

Author Affiliations +

Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 112110I (2020) https://doi.org/10.1117/12.2545320
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

A port-wine stain is a congenital vascular malformation, which may worsen if left untreated. Selective photothermolysis with Pulse-dye lasers is a well-established treatment for PWS. However, outcomes are often unpredictable due to tissue heterogeneity. This study characterizes the three-dimensional architecture of ex vivo human skin from control and PWS regions of five patients before and after laser treatment using optical coherence tomography (OCT), two-photon excitation fluorescence microscopy (TPEM), and second harmonic generation (SHG). Results suggest that combining the high penetration depth of OCT with the high resolution of multiphoton imaging could provide a means for real-time guidance of selective phototherapy.

Conference Presentation

Citation Download Citation

Iván Coto Hernández, Nate Jowett, and Tan Oon "Optimizing selective phototherapy of port wine stain by two-photon fluorescence and optical coherence tomography imaging (Conference Presentation)", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110I (6 March 2020); https://doi.org/10.1117/12.2545320

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