Development of photodynamic diagnosis and therapy for peritoneal dissemination using NIR fiber laser system

Y. Shirasaka; Y. Oshima; T. Inoue; Y. Maeda; T. Hiratsuka; T. Akagi; K. Suzuki; T. Shibata; Y. Ueda; M. Tojigamori; H. Shiroshita; T. Etoh; N. Shiraishi; M. Inomata

doi:10.1117/12.2546958

19 February 2020 Development of photodynamic diagnosis and therapy for peritoneal dissemination using NIR fiber laser system

Y. Shirasaka, Y. Oshima, T. Inoue, Y. Maeda, T. Hiratsuka, T. Akagi, K. Suzuki, T. Shibata, Y. Ueda, M. Tojigamori, H. Shiroshita, T. Etoh, N. Shiraishi, M. Inomata

Author Affiliations +

Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 112200A (2020) https://doi.org/10.1117/12.2546958
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Photodynamic diagnosis and therapy (PDD and PDT) involve the use of photochemical reactions induced by light irradiation with a photosensitizer for the detection and treatment of cancer cells and tissues. 5-Aminolevukinic acid (5-ALA) is a clinically used drug for PDT (5-ALA-PDT) in glioblastoma and bladder cancer. However, the conventional 5-ALA-PDT using visible light sours is not effective for the deep portion of organs and tissues. In this study, to overcome the limitation in penetration depth of 5-ALA-PDT, we developed two-photon excited 5-ALA-PDT system with NIR fiber laser for the effective treatment of peritoneal dissemination in gastric cancer.

Conference Presentation

Citation Download Citation

Y. Shirasaka, Y. Oshima, T. Inoue, Y. Maeda, T. Hiratsuka, T. Akagi, K. Suzuki, T. Shibata, Y. Ueda, M. Tojigamori, H. Shiroshita, T. Etoh, N. Shiraishi, and M. Inomata "Development of photodynamic diagnosis and therapy for peritoneal dissemination using NIR fiber laser system", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200A (19 February 2020); https://doi.org/10.1117/12.2546958

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available