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10 March 2020 Photodynamic inactivation using curcumin-loaded Pluronic® F-127 over Streptococcus mutans biofilm (Conference Presentation)
Alessandra Nara de Souza Rastelli, Diego Dantas Lopes dos Santos, João Felipe Bessegato, Joao Augusto Oshiro Jr., Marlus Chorilli, Vanderlei S. Bagnato
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Proceedings Volume 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020; 112230J (2020) https://doi.org/10.1117/12.2545296
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Photodynamic inactivation (PDI) is described as a promising therapy for oral inactivation. Due to the low aqueous solubility of curcumin, appropriate delivery systems are required to facilitate its use as a photosensitizer. This study evaluated the effectiveness of on Streptococcus mutans biofilm using curcumin-loaded Pluronic® 127. The micelles were characterized by different techniques. MIC and MBC were determined, and after that the cell viability of the biofilm irradiated by blue LED was obtained by CFU/mL and by confocal microscopy. Curcumin-loaded Pluronic® F-127 micelles can be a viable alternative for curcumin to improve the water solubility and the antimicrobial photodynamic effect.
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Alessandra Nara de Souza Rastelli, Diego Dantas Lopes dos Santos, João Felipe Bessegato, Joao Augusto Oshiro Jr., Marlus Chorilli, and Vanderlei S. Bagnato "Photodynamic inactivation using curcumin-loaded Pluronic® F-127 over Streptococcus mutans biofilm (Conference Presentation)", Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230J (10 March 2020); https://doi.org/10.1117/12.2545296
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KEYWORDS
Light emitting diodes
Confocal microscopy
Dynamic light scattering
Microorganisms
Photodynamic therapy
Polymers
Transmission electron microscopy
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