Understanding opioid-induced metabolic changes in brain and neurons using label-free multimodal nonlinear optical imaging (Conference Presentation)

Chi Zhang; Jaena Park; Carlos Renteria; Eric Chaney; Stephen A. Boppart

doi:10.1117/12.2546179

9 March 2020 Understanding opioid-induced metabolic changes in brain and neurons using label-free multimodal nonlinear optical imaging (Conference Presentation)

Chi Zhang, Jaena Park, Carlos Renteria, Eric Chaney, Stephen A. Boppart

Author Affiliations +

Proceedings Volume 11226, Neural Imaging and Sensing 2020; 112260O (2020) https://doi.org/10.1117/12.2546179
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

It is still unclear how neuronal metabolism is affected by opioids. We developed a multimodal nonlinear optical imaging platform that can resolve single neurons while monitoring endogenous metabolic molecules in a label-free manner. These capabilities enable investigation of morphine-induced metabolic changes in neurons. Additionally, mouse brain slices were used to study the effects of morphine on metabolism in the brain. We found that after morphine exposure, the nucleus accumbens area showed increased metabolic activity compared to the cerebral cortex. Further studies will reveal how opioids alter the metabolism of the brain and individual neurons at the sub-cellular level.

Conference Presentation

Citation Download Citation

Chi Zhang, Jaena Park, Carlos Renteria, Eric Chaney, and Stephen A. Boppart "Understanding opioid-induced metabolic changes in brain and neurons using label-free multimodal nonlinear optical imaging (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260O (9 March 2020); https://doi.org/10.1117/12.2546179

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