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Optical neuroimaging technologies aim to observe neural tissue structure and function by detecting changes in optical signals (scatter, absorption, etc…) that accompany a range of anatomical and functional properties of brain tissue. At present, there is a tradeoff between spatial and temporal resolution that is not currently optimized in a single imaging modality. We have developed a coherent optical imaging approach that begins to remove this trade-off and have demonstrated high spatiotemporal (<100µm and >100Hz) in-vivo recordings of neural activity over large 20mm2 areas.
David W. Blodgett,Carissa Rodriguez,Eyal Bar-Kochba,Clara Scholl,Nicole Steiner,Austen Lefebvre, andMarek Mirski
"In-vivo imaging of neurological signatures using coherent optical techniques (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260S (9 March 2020); https://doi.org/10.1117/12.2548582
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David W. Blodgett, Carissa Rodriguez, Eyal Bar-Kochba, Clara Scholl, Nicole Steiner, Austen Lefebvre, Marek Mirski, "In-vivo imaging of neurological signatures using coherent optical techniques (Conference Presentation)," Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260S (9 March 2020); https://doi.org/10.1117/12.2548582