Optical virtual skin biopsy using two-color ultrafast fiber laser

Hsiang-Yu Chung; Rüdiger Greinert; Franz X. Kärtner; Guoqing Chang

doi:10.1117/12.2556649

21 February 2020 Optical virtual skin biopsy using two-color ultrafast fiber laser

Hsiang-Yu Chung, Rüdiger Greinert, Franz X. Kärtner, Guoqing Chang

Proceedings Volume 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 112340Z (2020) https://doi.org/10.1117/12.2556649
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We demonstrate label-free multimodal multiphoton microscopy in human skin tissue with an ultrafast Er:fiber-laserbased source that emits femtosecond pulses at 775 nm and 1250 nm. This novel two-color fiber-based source enables second-harmonic generation, third-harmonic generation, and two-photon excitation fluorescence, which serves as a potential solution to optical virtual skin biopsy with compactness, robustness, and cost-effectiveness.

Citation Download Citation

Hsiang-Yu Chung, Rüdiger Greinert, Franz X. Kärtner, and Guoqing Chang "Optical virtual skin biopsy using two-color ultrafast fiber laser", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340Z (21 February 2020); https://doi.org/10.1117/12.2556649

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