OCT-based strain mapping and compression optical coherence elastography to study and control laser-assisted modification of avascular collagenous tissues

Vladimir Y. Zaitsev; Alexander L. Matveyev; Lev A. Matveev; Alexander A. Sovetsky; Olga I. Baum; Alexey V. Yuzhakov; A. I. Omelchenko; Emil N. Sobol

doi:10.1117/12.2549227

13 February 2020 OCT-based strain mapping and compression optical coherence elastography to study and control laser-assisted modification of avascular collagenous tissues

Vladimir Y. Zaitsev, Alexander L. Matveyev, Lev A. Matveev, Alexander A. Sovetsky, Olga I. Baum, Alexey V. Yuzhakov, A. I. Omelchenko, Emil N. Sobol

Author Affiliations +

Proceedings Volume 11242, Optical Elastography and Tissue Biomechanics VII; 1124202 (2020) https://doi.org/10.1117/12.2549227
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We consider application of optical coherence elastography (OCE) to problems of laser-assisted structural modification/reshaping of avascular collagenous tissues used for fabrication of cartilaginous implants and corneal tissue reshaping for perspective technologies of vision-correction. The developed OCE technique allows one to quantitatively visualize aperiodic strains during the IR-laser irradiation of the tissue samples and evaluate cumulative strains produced by the laser irradiations. OCE can assess stability of laser-modeled implants via monitoring of post-irradiation slow strains and to study the interplay of temperature and thermal stresses to optimize tissue reshaping. Irradiation-induced micro-porosity in the tissue can be assessed via combination of strain mapping with compressional optical elastography.

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Vladimir Y. Zaitsev, Alexander L. Matveyev, Lev A. Matveev, Alexander A. Sovetsky, Olga I. Baum, Alexey V. Yuzhakov, A. I. Omelchenko, and Emil N. Sobol "OCT-based strain mapping and compression optical coherence elastography to study and control laser-assisted modification of avascular collagenous tissues", Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 1124202 (13 February 2020); https://doi.org/10.1117/12.2549227

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