Monitoring protein receptor interactions in live cells using SERS

Zachary D. Schultz

doi:10.1117/12.2567272

20 August 2020 Monitoring protein receptor interactions in live cells using SERS

Zachary D. Schultz

Proceedings Volume 11468, Enhanced Spectroscopies and Nanoimaging 2020; 114680G (2020) https://doi.org/10.1117/12.2567272
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

The ability to monitor biochemical events in living cells is important in applications such as drug targeting and for understanding biological pathways. The enhancement of Raman signals by plasmonic nanoparticles, surface enhanced Raman scattering (SERS), or by a metalized scanning probe tip, tip enhanced Raman scattering (TERS), provide high sensitivity methods for exploring biological molecules in living cells. In this report we will examine how the Raman signals observed from functionalized nanoparticles can be used to study and differentiate protein receptor recognition based on the Raman signal observed. We will demonstrate the application of this technique in live cells. We will also examine the chemical origins of the observed signal to further elucidate the utility of these approaches.

Conference Presentation

Citation Download Citation

Zachary D. Schultz "Monitoring protein receptor interactions in live cells using SERS", Proc. SPIE 11468, Enhanced Spectroscopies and Nanoimaging 2020, 114680G (20 August 2020); https://doi.org/10.1117/12.2567272

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