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15 February 2021 Single-kV multi-contrast x-ray imaging for gout detection and gout-pseudogout differentiation
Daniel H. Bushe, Ran Zhang, Xu Ji, Mang Feng, Guang-Hong Chen, Ke Li
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Proceedings Volume 11595, Medical Imaging 2021: Physics of Medical Imaging; 115951P (2021) https://doi.org/10.1117/12.2580972
Event: SPIE Medical Imaging, 2021, Online Only
Abstract
Gout is the most prevalent inflammatory arthritis found in men. A prompt diagnosis and early treatment of gout are crucial in preventing eventual functional impairment and reduction in comorbidities. In this work, the quantitative material information provided by a multi-contrast x-ray (MCXR) imaging acquisition is leveraged to develop a rapid, non-invasive, and low dose diagnostic method for gout detection and gout-pseudogout differentiation. This work establishes a theoretical foundation to demonstrate how a single-kV MCXR acquisition is capable of differentiating gout from pseudogout via a projection domain two-material decomposition. Experimental results from a benchtop MCXR system are presented. The imaging performance of the proposed MCXR technique is compared to dual-energy radiography to further validate the method.
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Daniel H. Bushe, Ran Zhang, Xu Ji, Mang Feng, Guang-Hong Chen, and Ke Li "Single-kV multi-contrast x-ray imaging for gout detection and gout-pseudogout differentiation", Proc. SPIE 11595, Medical Imaging 2021: Physics of Medical Imaging, 115951P (15 February 2021); https://doi.org/10.1117/12.2580972
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KEYWORDS
X-ray imaging
Crystals
Crystallography
Diagnostics
Imaging systems
Calcium
Numerical simulations
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