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Blood flow measurement in deep tissue is important because the circulatory system transports oxygen and nutrition to the tissue and removes carbon dioxide out from the tissue. Several non-invasive optical methods were developed for blood flow measurement in deep tissue, such as diffuse correlation spectroscopy (DCS) and diffuse speckle contrast analysis (DSCA). In this paper we will introduce a new speckle-based method for fast blood flow measurement in deep tissue: diffuse speckle pulsatile flowmetry (DSPF). By using a multi-mode fiber for speckle pattern detection, DSPF achieves high blood flow measurement rate of 300 Hz. It has one of the fastest measurement rates of blood flow among non-invasive modalities.
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Renzhe Bi, Yao Du, Amalina Attia, Jun-Hui Chris Ho, Malini Olivo, "A speckle-based method for fast blood flow measurement in deep tissue," Proc. SPIE 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1163606 (5 March 2021); https://doi.org/10.1117/12.2578106