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In this presentation, we will present a general biosensor technology capable of continuously tracking a wide range of molecules in living subjects. Our real-time biosensor requires no exogenous reagents and can be readily reconfigured to measure different target molecules by exchanging molecular probes in a modular manner. Next, we will present the first real-time, closed loop feedback control of drug concentration in live animals using the real-time biosensor and discuss potential applications of our technology. Finally, we will discuss methods for generating synthetic molecular switches that are at the heart of the biosensor.
Hyongsok T. Soh
"Real-time biosensors for continuous measurements of specific biomolecules in vivo", Proc. SPIE 11663, Integrated Sensors for Biological and Neural Sensing, 116630T (5 March 2021); https://doi.org/10.1117/12.2580234
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Hyongsok T. Soh, "Real-time biosensors for continuous measurements of specific biomolecules in vivo," Proc. SPIE 11663, Integrated Sensors for Biological and Neural Sensing, 116630T (5 March 2021); https://doi.org/10.1117/12.2580234