Quantifying nanoscale changes in photoreceptors: a new approach to assessing cell function and health

Donald T. Miller

doi:10.1117/12.2602087

23 June 2021 Quantifying nanoscale changes in photoreceptors: a new approach to assessing cell function and health

Donald T. Miller

Proceedings Volume 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V; 1178607 (2021) https://doi.org/10.1117/12.2602087
Event: SPIE Optical Metrology, 2021, Online Only

Abstract

Vision starts when light is captured by photoreceptors, specialized cells in the retina that set fundamental limits on what we can see and are unfortunately lost in many blinding diseases. While photoreceptors carry considerable clinical and scientific importance in ophthalmology and vision science, means to assess their function and health at the level of individual cells remain limited. Recent advances in adaptive optics optical coherence tomography (AO-OCT) imaging systems have enabled photoreceptor cells to be observed and tracked with unprecedented 3D resolution and sensitivity in the living human eye. This imaging capability has allowed the dynamics of these cells to be studied in exquisite detail, in particular nanoscale transients the cells generate after being stimulated by light. These changes have been found to carry fundamental information about the photoreceptor’s physiology. Here, I will describe the capability of AO-OCT to image, track, and quantify these miniscule cell dynamics and how these measurements are being used to study vision and to assess cell dysfunction and health in disease.

Conference Presentation

Citation Download Citation

Donald T. Miller "Quantifying nanoscale changes in photoreceptors: a new approach to assessing cell function and health", Proc. SPIE 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, 1178607 (23 June 2021); https://doi.org/10.1117/12.2602087

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