Mathematical modeling of cavity development in lung tuberculosis

Anastasia I. Lavrova; Eugene B. Postnikov; Diljara S. Esmedljaeva

doi:10.1117/12.2588475

4 May 2021 Mathematical modeling of cavity development in lung tuberculosis

Anastasia I. Lavrova, Eugene B. Postnikov, Diljara S. Esmedljaeva

Proceedings Volume 11847, Saratov Fall Meeting 2020: Computations and Data Analysis: from Molecular Processes to Brain Functions; 1184707 (2021) https://doi.org/10.1117/12.2588475
Event: Saratov Fall Meeting 2020, 2020, Saratov, Russian Federation

Abstract

Lung tuberculosis caused by Micobacterium tuberculosis is still one of the leading killers today. Different computational models have been developed to find new clues to understand this mortal disease. Up until now these models lacked up-to-date visualization tools that allow dynamic exploratory data analysis. We have developed model based on the study of “manipulation" by immune signalling and biochemical metabolic pathways by M. tuberculosis that reveal key factors contributing either to the beginning of reparative changes or the transition of the disease to a chronic form. We have defined deploying the mathematical model and being based on published clinical observations, "key parameters" stimulating the restoration of the structure and functions of tissues, as well as analyzed the dynamics of cellular populations for the diagnosis of functional and pathological conditions of the host.

Citation Download Citation

Anastasia I. Lavrova, Eugene B. Postnikov, and Diljara S. Esmedljaeva "Mathematical modeling of cavity development in lung tuberculosis", Proc. SPIE 11847, Saratov Fall Meeting 2020: Computations and Data Analysis: from Molecular Processes to Brain Functions, 1184707 (4 May 2021); https://doi.org/10.1117/12.2588475

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available