Label-free imaging of spinal cords injured tissues with multiphoton microscopy

Xiwen Chen; Shuang Wang; Jianxin Chen

doi:10.1117/12.2601049

9 October 2021 Label-free imaging of spinal cords injured tissues with multiphoton microscopy

Xiwen Chen, Shuang Wang, Jianxin Chen

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119001U (2021) https://doi.org/10.1117/12.2601049
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Conference Poster

Abstract

The spinal cord injury (SCI) is a common disease of the central nervous system. Early diagnosis and assessment of patients with SCI in favor of timely treatment, can help patients recover from illness as soon as possible. In this study, we use multiphoton microscopy (MPM) to obtain the high-resolution images of fresh, unfixed, unstained rat spinal cord specimens (normal spinal cord tissue and the tissue of SCI). Our results show that MPM has great potential to identify the characteristics of SCI including the changes in the proliferation and hypertrophy of astrocytes and bleeding area. With the development of MPM, this technique can act as an efficient tool for early diagnosis and assessment of SCI.

Citation Download Citation

Xiwen Chen, Shuang Wang, and Jianxin Chen "Label-free imaging of spinal cords injured tissues with multiphoton microscopy", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119001U (9 October 2021); https://doi.org/10.1117/12.2601049

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