Tumor vascular feature based on speckle variance optical coherence tomography

Weijie Wu; Qian Liu; Zaifan Wang; Shulian Wu

doi:10.1117/12.2601089

9 October 2021 Tumor vascular feature based on speckle variance optical coherence tomography

Weijie Wu, Qian Liu, Zaifan Wang, Shulian Wu

Author Affiliations +

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119001W (2021) https://doi.org/10.1117/12.2601089
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Conference Poster

Abstract

Microvascular network distributes all around the body. Blood vessel is the main channel of tumor development and metastasis, and it is also the channel of drug therapy. So, the tumor vessel feature is very important for characterizing the tumor progress. In our study, OCT was applied on capturing the structure of normal and tumor tissue. Speckle variance algorithm was used to deduce vessel information. And then, vessel character, such as measurable diameters of lumen in blood vessels, vessels tortuosity index and vessel density of vascular between normal vessel and tumor vessel were displayed quantitatively. The result could uncover the difference between the normal and tumor vessel and will help to understand tumor angiogenesis.

Citation Download Citation

Weijie Wu, Qian Liu, Zaifan Wang, and Shulian Wu "Tumor vascular feature based on speckle variance optical coherence tomography", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119001W (9 October 2021); https://doi.org/10.1117/12.2601089

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