Asher C. Park,1 Zhikai Zhuhttps://orcid.org/0000-0002-1447-3170,1,2 Lidek Chou,1 Katelyn Dilley,3 Akarsh Lal,1 Edward C. Kuan,2 Zhongping Chen,1,2 Brian J. F. Wong1,2
1Beckman Laser Institute (United States) 2Univ. of California, Irvine (United States) 3Beckman Laser Institute (United States)
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Mucociliary clearance facilitated by healthy cilia beating is crucial to normal upper airway function. Phase-contrast microscopy (PCM) is the current golden standard for measuring ciliary beat frequency (CBF) and has limitations. With PCM, one cannot appreciate how CBF varies across the complex landscape of the nasal vault and sinus tissues. With Spectrally encoded interferometric microscopy (SEIM), en face imaging of cilia can be achieved, providing insight into the changes in CBF across tissue surfaces. This study aims to validate the use of SEIM to quantify ciliary beat frequency across ex vivo upper airway tissue.
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Asher C. Park, Zhikai Zhu, Lidek Chou, Katelyn Dilley, Akarsh Lal, Edward C. Kuan, Zhongping Chen, Brian J. F. Wong, "Validation of spectrally encoded interferometric microscopy (SEIM) in finding ciliary beat frequency of human ex vivo upper airway tissue," Proc. SPIE 11935, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2022, 1193505 (9 March 2022); https://doi.org/10.1117/12.2607390