1Beckman Laser Institute and Medical Clinic, Univ. of California, Irvine (United States) 2The Geneva Foundation (United States) 3U.S. Army Institute of Surgical Research (United States)
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Acute Respiratory Distress Syndrome (ARDS) is a severe form of lung injury characterized by hypoxemia. ARDS is estimated to affect at least 190,000 patients per year in the United States. The median time for ARDS onset is 48 hours after hospital admission. The early assessment of the ARDS due to smoke inhalation injury (SII) plays a vital role in facilitating appropriate treatment strategies and improved clinical outcomes. Optical coherence tomography (OCT) may be used as an effective diagnostic tool in quantifying the physiological changes in the airway after smoke inhalation injury. The objective of this study is to develop and evaluate a deep-learning technique to predict and early uncover (within 24 hours) ARDS in a pig model based on the information obtained from the OCT images. A convolutional neural network (CNN) is modeled to train and classify the pig airway images. The early prediction would help clinicians in the accurate diagnosis of ARDS which is of great clinical value.
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