Optimizing the protocol for retinal vascular permeability mapping from fluorescein video angiography data

Elif Kayaalp-Nalbant; Laasya Annepureddy; Shaoxian Hu; Wenqiang Liu; Fangyao Tang; Zihan Sun; Carol Y. Cheung; William F. Mieler; Jennifer J. Kang-Mieler; Kenneth M. Tichauer

doi:10.1117/12.2610279

4 March 2022 Optimizing the protocol for retinal vascular permeability mapping from fluorescein video angiography data

Elif Kayaalp-Nalbant, Laasya Annepureddy, Shaoxian Hu, Wenqiang Liu, Fangyao Tang, Zihan Sun, Carol Y. Cheung, William F. Mieler, Jennifer J. Kang-Mieler, Kenneth M. Tichauer

Author Affiliations +

Proceedings Volume 11941, Ophthalmic Technologies XXXII; 119410K (2022) https://doi.org/10.1117/12.2610279
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

An intact blood-retinal barrier is critical to maintaining the function of the retina. Many diseases of the eye have been directly associated with impairment in vascular permeability, and methods to measure vascular permeability could offer a window into early detection of disease; however, there exist no direct measures of vascular permeability that have be translated to the clinic. This work details a complete clinical workflow to quantify vascular permeability and volumetric blood flow from fluorescein videoangiography data, with validation through realistic simulations. For optimizing the protocol, this study carried on frame rate of fluorescein videoangiography to generate a high-resolution image while minimizing the error.

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Elif Kayaalp-Nalbant, Laasya Annepureddy, Shaoxian Hu, Wenqiang Liu, Fangyao Tang, Zihan Sun, Carol Y. Cheung, William F. Mieler, Jennifer J. Kang-Mieler, and Kenneth M. Tichauer "Optimizing the protocol for retinal vascular permeability mapping from fluorescein video angiography data", Proc. SPIE 11941, Ophthalmic Technologies XXXII, 119410K (4 March 2022); https://doi.org/10.1117/12.2610279

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