Metrology of tissue pathology using optical self-healing

Mbaye Diouf; Zixi Lin; Kimani C. Toussaint Jr.

doi:10.1117/12.2609161

2 March 2022 Metrology of tissue pathology using optical self-healing

Mbaye Diouf, Zixi Lin, Kimani C. Toussaint Jr.

Proceedings Volume 11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology; 1195805 (2022) https://doi.org/10.1117/12.2609161
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

In this work, we study the self-healing properties of the space-time (ST) light sheet upon interaction with a partially transparent object, namely a microtissue array of biological samples. In particular, we study the response of the ST light sheet upon encountering biological tissues that have been graded as normal (benign), malignant, and malignant tumor stage III. We find a differential response that can be leveraged for characterization of the tissue specimens. Specifically, the ST light sheet is observed to more completely reconstruct upon traversing the normal tissue compared to the malignant specimens. We believe that this is the first report exploring the potential of self-healing as a metric for tissue characterization.

Citation Download Citation

Mbaye Diouf, Zixi Lin, and Kimani C. Toussaint Jr. "Metrology of tissue pathology using optical self-healing", Proc. SPIE 11958, Optical Interactions with Tissue and Cells XXXIII; and Advanced Photonics in Urology, 1195805 (2 March 2022); https://doi.org/10.1117/12.2609161

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KEYWORDS

Tissue optics

Tumors

Tissues

Pathology

Metrology

Bessel beams

Diffraction gratings

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