Effects of high intensity non-ionizing pulses of terahertz radiation on human skin fibroblasts

Veronika A. Revkova; Inna V. Ilina; Svetlana A. Gurova; Rimma O. Shatalova; Mikhail A Konoplyannikov; Vladimir A. Kalsin; Vladimir P. Baklaushev; Dmitry S. Sitnikov

doi:10.1117/12.2606188

3 March 2022 Effects of high intensity non-ionizing pulses of terahertz radiation on human skin fibroblasts

Veronika A. Revkova, Inna V. Ilina, Svetlana A. Gurova, Rimma O. Shatalova, Mikhail A Konoplyannikov, Vladimir A. Kalsin, Vladimir P. Baklaushev, Dmitry S. Sitnikov

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Proceedings Volume 11975, Advances in Terahertz Biomedical Imaging and Spectroscopy; 1197504 (2022) https://doi.org/10.1117/12.2606188
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Data on the effects of high-intensity pulsed THz radiation (peak intensity ~30 GW/cm2 , electric field strength ~3.5 MV/cm) on human skin fibroblasts have been obtained for the first time. A quantitative assessment of the number of histone H2AX phosphorylation foci in a cell as a function of irradiation time and THz pulse energy was obtained. It has been shown that the appearance of foci is not associated with either oxidative (cells retain their morphology, cytoskeleton structure, and the content of reactive oxygen species does not exceed the control values) or thermal stress. Long-term irradiation of cells did not reduce their proliferative index.

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Veronika A. Revkova, Inna V. Ilina, Svetlana A. Gurova, Rimma O. Shatalova, Mikhail A Konoplyannikov, Vladimir A. Kalsin, Vladimir P. Baklaushev, and Dmitry S. Sitnikov "Effects of high intensity non-ionizing pulses of terahertz radiation on human skin fibroblasts", Proc. SPIE 11975, Advances in Terahertz Biomedical Imaging and Spectroscopy, 1197504 (3 March 2022); https://doi.org/10.1117/12.2606188

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