How cold waves influence LDL cholesterol levels? A regional study for Campinas, São Paulo, Brazil

Thiago R. Bella; Júlia P. De Lázari; Welington Corozolla; Daniela S. de Oliveira; Ana M. Heuminski de Avila; Eliana C. de Faria; Paula D. Paro Costa

doi:10.1117/12.2606220

10 December 2021 How cold waves influence LDL cholesterol levels? A regional study for Campinas, São Paulo, Brazil

Thiago R. Bella, Júlia P. De Lázari, Welington Corozolla, Daniela S. de Oliveira, Ana M. Heuminski de Avila, Eliana C. de Faria, Paula D. Paro Costa

Author Affiliations +

Proceedings Volume 12088, 17th International Symposium on Medical Information Processing and Analysis; 120881G (2021) https://doi.org/10.1117/12.2606220
Event: Seventeenth International Symposium on Medical Information Processing and Analysis, 2021, Campinas, Brazil

Abstract

The increase in deaths from cardiovascular diseases in extreme temperature events, particularly during cold waves, is a phenomenon already reported in the literature. One of its mechanisms is the increased likelihood of atherosclerotic plaque formation due to higher concentrations of low-density lipoprotein (LDL-C) in the blood at periods of lower temperatures. This study adopts a data science approach to check evidences of this mechanism in the population of Campinas, a city in the southeast region of Brazil, with over 1 million inhabitants. We integrated climate and health datasets and processed over 1,677,424 LDL-C exam results in combination with minimum and maximum daily air temperature data in the city in eleven years (2008-2018). The data were stratified into sex and age groups, and we analyzed the difference in distributions of LDL-C levels for those exposed to cold waves versus control days. Cold waves were defined as at least three consecutive days with minimum and maximum temperatures below their 10th percentiles, considering a 30-year climate normal (1961- 1990). In particular, we analyzed the effect of cold waves on LDL-C levels above reference value. Our analyses identified nine cold waves in the period and statistically relevant effects on exam results. The amount LDL-C exams with levels above reference value was 3.32% greater for women between 20 and 65 years old (lag 2), 9.27%, 7.39% and 4.06% for women over 65 (lags 0, 2 and 7, respectively), and 11.45% for men over 65 (lag 4).

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Thiago R. Bella, Júlia P. De Lázari, Welington Corozolla, Daniela S. de Oliveira, Ana M. Heuminski de Avila, Eliana C. de Faria, and Paula D. Paro Costa "How cold waves influence LDL cholesterol levels? A regional study for Campinas, São Paulo, Brazil", Proc. SPIE 12088, 17th International Symposium on Medical Information Processing and Analysis, 120881G (10 December 2021); https://doi.org/10.1117/12.2606220

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KEYWORDS

Climate change

Databases

Statistical analysis

Blood

Environmental sensing

Pathology

Cardiovascular disorders

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