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29 April 2022 Study of the effectiveness of aqueous dispersion of gold nanoparticles as a potential photosensitizer for photodynamic antimicrobial therapy
Olga V. Nechaeva, Tatiana A. Shulgina, Elena V. Glinskaya, Ksenia V. Zubova, Dmitry A. Shnaider, Matve I. Nikelshparg, Natalya V. Bespalova
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Proceedings Volume 12194, Computational Biophysics and Nanobiophotonics; 1219414 (2022) https://doi.org/10.1117/12.2626361
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation
Abstract
The object of the study was an aqueous dispersion of gold nanoparticles stabilized with polyvinyl alcohol (AuPVA). It was previously found that AuPVA is characterized by a broad spectrum of antimicrobial activity against standard and clinical strains of gram-positive and gram-negative bacteria and yeasts. The safety of using AuPVA is associated with the absence of toxic effects of its working concentrations on biotest objects and cell cultures. Evaluation of the effectiveness of photodynamic antimicrobial therapy was carried out on a model of experimental full-sleep purulent wounds, which were formed in the interscapular region in rats. We used a semiconductor laser with a wavelength of 405 nm (manufactured by AlcomMedica, St. Petersburg). It was found that the use of 1% aqueous dispersion of AuPVA as a photosensitizer led to a 1,6-fold reduction in the wound healing time compared to the control.
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Olga V. Nechaeva, Tatiana A. Shulgina, Elena V. Glinskaya, Ksenia V. Zubova, Dmitry A. Shnaider, Matve I. Nikelshparg, and Natalya V. Bespalova "Study of the effectiveness of aqueous dispersion of gold nanoparticles as a potential photosensitizer for photodynamic antimicrobial therapy", Proc. SPIE 12194, Computational Biophysics and Nanobiophotonics, 1219414 (29 April 2022); https://doi.org/10.1117/12.2626361
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KEYWORDS
Photodynamic therapy
Nanoparticles
Gold
Semiconductor lasers
Wound healing
Manufacturing
Microorganisms
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