Ideal light scatterer for near-infrared spectroscopy tissue mimicking phantoms

Rasa Eskandari; Mamadou Diop

doi:10.1117/12.2649524

7 March 2023 Ideal light scatterer for near-infrared spectroscopy tissue mimicking phantoms

Rasa Eskandari, Mamadou Diop

Proceedings Volume 12376, Optical Tomography and Spectroscopy of Tissue XV; 1237605 (2023) https://doi.org/10.1117/12.2649524
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Tissue mimicking phantoms are widely used to test and validate near-infrared spectroscopy (NIRS) devices and algorithms. The two main constituents of phantoms for NIRS applications are a light scatterer, typically Intralipid, and one or multiple light-absorbing dyes, which are most commonly methylene blue, indocyanine green (ICG), and India ink. The current study investigated the spectral shape of tissue mimicking phantoms made of different combinations of Intralipid and these three dyes. The results reveal that Intralipid interacts with the dyes and alters their molar extinction coefficients, thereby hindering the ability to accurately estimate the phantom chromophore concentrations when either the dye or scatterer concentrations change. Furthermore, inorganic light scatterers, such as glass microspheres and titanium oxide, have less interaction with the dyes, with glass microspheres being the least interactive and therefore the best scatterer. These findings are significant, because NIRS phantoms continue to depend on methylene blue, ICG, and India ink as chromophores. Therefore, glass microspheres should be used as a light scatterer instead of Intralipid, which is currently the most common scatterer for NIRS liquid phantoms.

Conference Presentation

Citation Download Citation

Rasa Eskandari and Mamadou Diop "Ideal light scatterer for near-infrared spectroscopy tissue mimicking phantoms", Proc. SPIE 12376, Optical Tomography and Spectroscopy of Tissue XV, 1237605 (7 March 2023); https://doi.org/10.1117/12.2649524

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