Distortion imaging and correction of emitter distortion near plasmonic nanostructure

Gwiyeong Moon; Taehwang Son; Hajun Yoo; Changhun Lee; Hyunwoong Lee; Seongmin Im; Donghyun Kim

doi:10.1117/12.2649462

16 March 2023 Distortion imaging and correction of emitter distortion near plasmonic nanostructure

Gwiyeong Moon, Taehwang Son, Hajun Yoo, Changhun Lee, Hyunwoong Lee, Seongmin Im, Donghyun Kim

Proceedings Volume 12396, Plasmonics in Biology and Medicine XX; 1239603 (2023) https://doi.org/10.1117/12.2649462
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Metallic nanostructures have the potential to be used in a variety of applications related to sensing and imaging biological molecules due to their ability to enhance the way molecules absorb and emit light. However, the interaction between metallic nanostructure and molecules can give rise to difficulty with determining precise molecular positions and orientations and therefore pose major challenges in the field of super-resolution imaging. In this work, we used axially defocused imaging to analyze the interaction between a single fluorescent molecule and a metallic nanostructure. In addition, a pattern matching algorithm was used to analyze the images, explore the interaction between the molecule and the nanostructure and thereby determine the lateral position. The accuracy was found to improve while the degree was dependent on the dipolar orientation and the distance between dipole and nanostructure. This approach has the potential to improve the reliability of using metallic nanostructures for imaging and sensing in the future and opens up new possibilities for various imaging and sensing methods.

Conference Presentation

Citation Download Citation

Gwiyeong Moon, Taehwang Son, Hajun Yoo, Changhun Lee, Hyunwoong Lee, Seongmin Im, and Donghyun Kim "Distortion imaging and correction of emitter distortion near plasmonic nanostructure", Proc. SPIE 12396, Plasmonics in Biology and Medicine XX, 1239603 (16 March 2023); https://doi.org/10.1117/12.2649462

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