Super-resolution ultrasound through localisation and tracking: technical developments and applications

Mengxing Tang

doi:10.1117/12.2655220

10 April 2023 Super-resolution ultrasound through localisation and tracking: technical developments and applications

Mengxing Tang

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Proceedings Volume 12470, Medical Imaging 2023: Ultrasonic Imaging and Tomography; 1247002 (2023) https://doi.org/10.1117/12.2655220
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Abstract

There has been an inherent compromise between the spatial resolution and penetration depth in ultrasound imaging. Optical super-resolution, through e.g. photo-activated localization microscopy (PALM), has overcome the diffraction limit of spatial resolution, although its penetration is limited to in vitro applications. Super-resolution ultrasound (SRUS), particularly through localizing spatially isolated individual microbubbles, is shown to be able to break the wave diffraction limit and generate microscopic resolution at centi-meter depth, offering great promises for a wide range of clinical applications. In the talk I would introduce the principles of super-resolution ultrasound through localisation and tracking, and our efforts in technical developments to address some of the current challenges in SRUS and exploring its clinical applications.

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Mengxing Tang "Super-resolution ultrasound through localisation and tracking: technical developments and applications", Proc. SPIE 12470, Medical Imaging 2023: Ultrasonic Imaging and Tomography, 1247002 (10 April 2023); https://doi.org/10.1117/12.2655220

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KEYWORDS

Super resolution

Ultrasonography

Diffraction

Spatial resolution

In vitro testing

Photo activated localization microscopy

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