Molecular imaging in Alzheimer's disease

Alina Dang

doi:10.1117/12.2669053

24 March 2023 Molecular imaging in Alzheimer's disease

Alina Dang

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126111C (2023) https://doi.org/10.1117/12.2669053
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Alzheimer’s disease is the most common cause of dementia, being a neurodegenerative, progressive disease that can be identified through different hallmarks such as tau protein buildup, amyloid plaque, and more. Through different types of molecular imaging, doctors are able to better diagnose and monitor Alzheimer’s disease. Through analyzing several different papers regarding molecular imaging’s role in Alzheimer’s disease, specifically MRI: split into fMRI and sMRI, PET: split into tau PET and Aβ PET, and SPECT imaging, the results show that molecular imaging does and can play an important role in Alzheimer’s disease, having relatively high accuracy rates for diagnosing. After thorough review of different studies, it is found that fMRI, Tau PET imaging, and Aβ PET imaging are very promising biomarkers of Alzheimer’s disease with relatively consistent high specificity, sensitivity, and diagnostic accuracy rates while sMRI and SPECT imaging results show that, although high, specificity, sensitivity, and diagnostic accuracy rates are either inconsistent or lower compared to the other molecular imaging techniques.

Citation Download Citation

Alina Dang "Molecular imaging in Alzheimer's disease", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126111C (24 March 2023); https://doi.org/10.1117/12.2669053

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KEYWORDS

Alzheimer's disease

Positron emission tomography

Brain diseases

Molecular imaging

Functional magnetic resonance imaging

Magnetic resonance imaging

Single photon emission computed tomography

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