Exploring recent advances and limitations in CAR-T therapy for glioblastoma multiforme

Sixing Luo

doi:10.1117/12.2669007

24 March 2023 Exploring recent advances and limitations in CAR-T therapy for glioblastoma multiforme

Sixing Luo

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126113R (2023) https://doi.org/10.1117/12.2669007
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Glioblastoma is among the most devastating brain tumors, with a high prevalence in all primary brain tumors. The rapid progression nature of malignant glioma with resistant relapse in current treatment leads to a low survival rate. Chimeric antigen receptor T therapy has the clinical potential to show groundbreaking success in many hematological malignancies convincingly. This scoping review aims to investigate the application of CAR-T-based immunotherapy on delaying the progression of glioblastoma multiforme and explore potential obstacles when conducting clinical trials. This study discusses key emerging factors that may contribute to treatment resistance and reported toxicities are observed in current clinical trials. Despite remaining questions in this innovative immunotherapy field, the encouraging response in multiple clinical trials paves a road for researchers to bring up new strategies to overcome these challenges.

Citation Download Citation

Sixing Luo "Exploring recent advances and limitations in CAR-T therapy for glioblastoma multiforme", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126113R (24 March 2023); https://doi.org/10.1117/12.2669007

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available