A novel design of COVID-19 vaccine with high effectiveness and popularization

Jielin Meng; Haotian Sun; Ruoyu Zhu

doi:10.1117/12.2669364

24 March 2023 A novel design of COVID-19 vaccine with high effectiveness and popularization

Jielin Meng, Haotian Sun, Ruoyu Zhu

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126115Z (2023) https://doi.org/10.1117/12.2669364
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

In December 2019, a virus named SARS-CoV-2 broke out in Wuhan in China. The spread of the virus has brought great challenges to the global medical system. At present, over 6 million people died of the diseases caused by the virus. Under these situations, various corresponding vaccines such as Oxford, Pfizer, and Moderna vaccines have been developed and applied to the population. Nevertheless, due to the development of variants of the virus such as Delta and Omicron, there has been a decline in the effectiveness of current vaccines to some extent. Moreover, the proportion of people who have been inoculated with the COVID-19 vaccine in low-income countries is less than 20%. In this case, we designed a new vaccine to deal with these problems. Specifically, we utilized the antigens (RBD, HR1, and HR2) of the virus to cope with its potential variants of it, increasing the effectiveness of the vaccine. Moreover, we designed a new cell expression system to increase the efficiency of vaccine production by using CHO cells as host cells, Neo gene as a selective marker, CMV as a promoter, MBP as affinity tag, and β-globin as a terminator. Eventually, it was worth stating that our designed vaccine was hypothesized to be practicable and functional, it just started one step on the way to tackling the variants of this virus and increasing the productivity of the vaccine. The detailed experiments still needed to be implemented to verify the feasibility of our design.

Citation Download Citation

Jielin Meng, Haotian Sun, and Ruoyu Zhu "A novel design of COVID-19 vaccine with high effectiveness and popularization", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126115Z (24 March 2023); https://doi.org/10.1117/12.2669364

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KEYWORDS

Proteins

COVID 19

Design and modelling

Antibodies

Resistance

Viruses

Safety

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