The role of animal models in the treatment of diabetes mellitus

Siqi Zhang

doi:10.1117/12.2692775

7 September 2023 The role of animal models in the treatment of diabetes mellitus

Siqi Zhang

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 1278929 (2023) https://doi.org/10.1117/12.2692775
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Diabetes mellitus is normally classified into type 1 diabetes and type 2 diabetes. The auto-immune malfunction of insulin-producing pancreatic beta cells is known to cause type 1 diabetes. Type 2 diabetes mellitus is triggered by insulin resistance and a beta cell inability to produce the required amount of insulin. Animal models of type 1 diabetes vary from mice that acquire auto-immune diabetes spontaneously to pharmacological ablation for pancreatic beta cells. Obese and non-obese are types of animal models with variable levels of insulin sensitivity and beta cell failure are used to simulate type 2 diabetes. This study discusses some current models utilized in treating T1DM and T2DM based on relevant literature and statistical data. The use of transgene and knockout mice models is also explored. An over-one animal model should ideally be utilized to mimic the variability exhibited in diabetes individuals. The research found that animal models have several advantages in treating diabetes, and success depends on the precision and animal model types used.

Citation Download Citation

Siqi Zhang "The role of animal models in the treatment of diabetes mellitus", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 1278929 (7 September 2023); https://doi.org/10.1117/12.2692775

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