Interference of SARS-CoV-2 on type Ⅰ IFN-mediated antiviral response

Lai Wei

doi:10.1117/12.2692178

7 September 2023 Interference of SARS-CoV-2 on type Ⅰ IFN-mediated antiviral response

Lai Wei

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127892T (2023) https://doi.org/10.1117/12.2692178
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Interferon's antiviral state is a key first line of defense against viral infection, but it is weakened and delayed by SARSCoV- 2, making COVID-19 difficult to treat. This dysregulated innate immune response may contribute to a critical disease or even death. Thus, to better control this virus and deal with possible pandemics of other coronaviruses in the future, we describe the host's innate sensing systems for SARS-CoV-2 and the virus's tactics to dodge the innate immune response, including processes used by SARS-CoV-2 proteins to avoid interferon activation and signaling in host cells. We review the evidence that SARS-CoV-2 proteins, specifically NSP1, 6, 13, and ORF6 proteins, inhibit both interferon induction and interferon-induced ISGs. Moreover, we highlight the contradictory findings due to the different screening and verifying systems. Finally, we discussed whether the blockade of IFN signaling by SARS-CoV-2 could be overcome by targeting interferon antagonists to restore the interferon-mediated antiviral response and achieve a cure.

Citation Download Citation

Lai Wei "Interference of SARS-CoV-2 on type Ⅰ IFN-mediated antiviral response", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127892T (7 September 2023); https://doi.org/10.1117/12.2692178

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