Feasibility of non-ablative photothermal 980nm laser endoluminal treatment for stress urinary incontinence

Hwarang Shin; Yeachan Lee; Seonghee Lim; Hyun Wook Kang

doi:10.1117/12.3002041

12 March 2024 Feasibility of non-ablative photothermal 980nm laser endoluminal treatment for stress urinary incontinence

Hwarang Shin, Yeachan Lee, Seonghee Lim, Hyun Wook Kang

Author Affiliations +

Proceedings Volume 12817, Advanced Photonics in Urology 2024; 1281705 (2024) https://doi.org/10.1117/12.3002041
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Stress urinary incontinence (SUI) is the involuntary leakage of urine during physical activity caused by bladder pressure exceeding urethral closure pressure. Slings are commonly used as a surgical treatment for SUI. However, the sling procedure is invasive and inserted into the body, resulting in mesh infection and chronic pain. The current study aims to evaluate the feasibility of laser treatment for SUI by using 980nm laser light with a balloon-integrated diffusing applicator as a minimally invasive and non-permanent procedure. A female porcine urethra was dilated using a balloon, and then the tissue was irradiated with the 980nm laser at 20W for 15s. The laser irradiated urethra were harvested 0, 14 and 28 days after the laser irradiation, respectively. Both Masson’s trichrome and Sirius red staining were applied to confirm structural changes and collagen distribution. There was no change in mucosal thickness between the laser irradiation group and the control group. In the laser irradiation group, the thickness of the muscle layer increased by approximately 35%, compared to the control group. Furthermore, the laser irradiation group showed a 30% increase in collagen distribution in the external urethral sphincter compared to the SUI model. The current study demonstrated the feasibility of the therapeutic effect of the 980nm laser in the porcine urethra. To confirm the safety and efficacy of the proposed photothermal treatment, we will conduct in vivo studies to assess the extent of nerve damage and molecular changes using PCR assays in chronic and disease-induced animal models.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Hwarang Shin, Yeachan Lee, Seonghee Lim, and Hyun Wook Kang "Feasibility of non-ablative photothermal 980nm laser endoluminal treatment for stress urinary incontinence", Proc. SPIE 12817, Advanced Photonics in Urology 2024, 1281705 (12 March 2024); https://doi.org/10.1117/12.3002041

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