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12 March 2024 Exploring photodynamic inactivation to combat antimicrobial resistance
Jennifer M. Soares, Vanderlei S. Bagnato, Kate C. Blanco
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Proceedings Volume 12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; 128220A (2024) https://doi.org/10.1117/12.3001705
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The rise of antimicrobial-resistant microorganisms prompts the exploration of strategies to rejuvenate traditional antibiotics. Photodynamic Inactivation (PDI) offers an alternative by combining a photosensitizer (PS) with light, generating reactive oxygen species that efficiently eliminate undesirable cells. In this study, curcumin and 450nm light are applied, resulting in reduced minimum inhibitory concentrations (MIC) for antibiotics. The application of PDI proves effective in diminishing the necessary antibiotic dosage for bacterial cell elimination, especially against resistant strains. Additionally, the interaction between the photosensitizer and antibiotics induces notable alterations in bacterial metabolism and biomolecules. These findings are crucial for advancing from in vitro studies to the clinical implementation of PDI as a promising adjunct to antibiotic therapy, offering potential solutions in the battle against antimicrobial resistance.
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Jennifer M. Soares, Vanderlei S. Bagnato, and Kate C. Blanco "Exploring photodynamic inactivation to combat antimicrobial resistance", Proc. SPIE 12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, 128220A (12 March 2024); https://doi.org/10.1117/12.3001705
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KEYWORDS
Bacteria
Resistance
Microorganisms
Oxygen
Antimicrobial agents
Molecular interactions
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