3D-printed nanoplasmonic device with super-hydrophobic sample concentrator for biosensing

Qinming Zhang; Gaurav Rawal; Jingjing Qian; Jianqiang Zhang; Liang Dong; Meng Lu

doi:10.1117/12.3000427

13 March 2024 3D-printed nanoplasmonic device with super-hydrophobic sample concentrator for biosensing

Qinming Zhang, Gaurav Rawal, Jingjing Qian, Jianqiang Zhang, Liang Dong, Meng Lu

Proceedings Volume 12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI; 128610D (2024) https://doi.org/10.1117/12.3000427
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

This work reports a 3D-printed virus sensing device that combines the functions of sample enrichment and quantification. The device consists of a nanoplasmonic biosensor surrounded by a biomimetic superhydrophobic structure. The superhydrophobic structure serves as a sample concentrator that can enrich the target analyte, which is subsequentially quantified by the nanoplasmonic biosensor. Both nanoscale sensor and microscale hydrophobic sample concentrator were fabricated using a high-resolution 3D printer through two-photon polymerization lithography (TPL). The design of the 3D-printed superhydrophobic microstructure was inspired by natural patterns found on surfaces like lotus leaves, which are known for their water-repellent properties. The TPP-based 3D printing approach enables the integration of two functions into one chip with a low-cost, high resolution, and simple fabrication process. This system was used to detect the swine influenza A virus contained in sample droplet with a starting volume of 25 μL. During a test, the droplet volume reduced due to evaporation, which was facilitated by the plasmonic heating. As a results the droplet’s diameter can shrink from 3.5 mm to 0.1 mm within 15 minutes. The volume reduction corresponds to the virus concentration increase over 4 × 10⁴ times. The implementation of superhydrophobic sample concentration around of the sensor significantly improved the immobilization of target viruses on the plasmonic sensor. The device not only achieved a higher sensitivity but also reduced the assay time.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Qinming Zhang, Gaurav Rawal, Jingjing Qian, Jianqiang Zhang, Liang Dong, and Meng Lu "3D-printed nanoplasmonic device with super-hydrophobic sample concentrator for biosensing", Proc. SPIE 12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI, 128610D (13 March 2024); https://doi.org/10.1117/12.3000427

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