Encapsulation of mechanoluminescent nanotransducers into erythrocyte-derived particles

G. Swajian; M. Gil Malinao; S. Jiang; C.-H. Lee; G. Hong; B. Anvari

doi:10.1117/12.3003223

13 March 2024 Encapsulation of mechanoluminescent nanotransducers into erythrocyte-derived particles

G. Swajian, M. Gil Malinao, S. Jiang, C.-H. Lee, G. Hong, B. Anvari

Proceedings Volume 12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; 1286202 (2024) https://doi.org/10.1117/12.3003223
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Mechanoluminescent nanotransducers (MLNTs) are colloidal materials that emit light upon mechanical excitation (e.g., by ultrasound activation). Encapsulation of MLNTs into erythrocyte-derived particles may provide a method to increase their circulation time. Herein, we have investigated three methods based on passive diffusion, sonoporation, and electroporation for loading of MLNTs. Confocal fluorescence imaging of the particles suggests that under the current protocols employed in this study, sonoporation and electroporation yielded better loading of the MLNTs into erythrocyte-derived particles.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

G. Swajian, M. Gil Malinao, S. Jiang, C.-H. Lee, G. Hong, and B. Anvari "Encapsulation of mechanoluminescent nanotransducers into erythrocyte-derived particles", Proc. SPIE 12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, 1286202 (13 March 2024); https://doi.org/10.1117/12.3003223

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