Pyroptosis and its role in gynecologic cancer

Wen Wang

doi:10.1117/12.3012826

8 January 2024 Pyroptosis and its role in gynecologic cancer

Wen Wang

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 1292404 (2024) https://doi.org/10.1117/12.3012826
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

A particularly inflammatory kind of programmed cell death is called pyroptosis. Inflammasomes, caspases, and GSDMs predominantly mediate its pathways. These molecules make up different signal pathways for pyroptosis and respond to specific triggers, which allow them to play a role in various diseases. In different types and stages of cancers, pyroptosis may have opposite effects. As the tumorigenesis progressed, the role of pyroptosis might change from promoting to inhibiting, and vice versa. The key regulatory factor of pyroptosis is inconsistent in different tumors. Gynecologic cancer affects the reproductive system of women. Pyroptosis has been implicated in the growth and spread of various malignancies. Among gynecologic cancers, ovarian cancer causes the most death. There is no effective early screening test for ovarian cancer and patients usually have poor prognosis. Pyroptosis-related genes that are expressed differently in cancer cells and normal cells are being studied to be used as signatures for better prediction of prognosis. Endometrial cancer is related to the periodic hormone changes that cause chronic inflammation, which is closely related to pyroptosis. Cervical cancer is mostly caused by HPV infection. HPV can inhibit pyroptosis pathways to help escape cell death. Pyroptosis provides a new target for cancer treatment. Its specific mechanisms in different tissue and possible side effects still need further studies.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Wen Wang "Pyroptosis and its role in gynecologic cancer", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 1292404 (8 January 2024); https://doi.org/10.1117/12.3012826

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KEYWORDS

Cancer

Tumors

Ovarian cancer

Cervical cancer

Cell death

Oncology

Radiotherapy

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