Evaluation of post radioligand therapy imaging methods for time integrated activity estimation: a Monte Carlo simulation-based approach

Zhihua Qi

doi:10.1117/12.3006828

3 April 2024 Evaluation of post radioligand therapy imaging methods for time integrated activity estimation: a Monte Carlo simulation-based approach

Zhihua Qi

Author Affiliations +

Proceedings Volume 12925, Medical Imaging 2024: Physics of Medical Imaging; 129254M (2024) https://doi.org/10.1117/12.3006828
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Conference Poster

Abstract

Precision radioligand therapy calls for patient dosimetry, which in turn requires the knowledge of time integrated activity curves for various tissues of interest, often acquired through post therapy imaging. A number of imaging methods have been proposed, with considerations of both dosimetric accuracy and the practicality of the method. Clinical studies on patients, as the more traditional way of evaluating these methods, are faced with challenges from: (1) the lack of ground truth and (2) the burden of performing the clinical studies. A Monte Carlo simulation based approach, as is proposed in this work, would address the challenges and provide fast and reliable ways to assess different imaging method. The presented work demonstrates the potential of the proposed simulation based approach in the the design of the post radioligand therapy imaging methods for patient dosimetry purposes.

Citation Download Citation

Zhihua Qi "Evaluation of post radioligand therapy imaging methods for time integrated activity estimation: a Monte Carlo simulation-based approach", Proc. SPIE 12925, Medical Imaging 2024: Physics of Medical Imaging, 129254M (3 April 2024); https://doi.org/10.1117/12.3006828

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