Photosensitizer concentration monitoring in photodynamic therapy of bladder by photoacoustic imaging technique

Dongqing Peng; Qiuqin Su; Haofang Yu

doi:10.1117/12.3006034

24 November 2023 Photosensitizer concentration monitoring in photodynamic therapy of bladder by photoacoustic imaging technique

Dongqing Peng, Qiuqin Su, Haofang Yu

Author Affiliations +

Proceedings Volume 12935, Fourteenth International Conference on Information Optics and Photonics (CIOP 2023); 129351J (2023) https://doi.org/10.1117/12.3006034
Event: Fourteenth International Conference on Information Optics and Photonics (CIOP 2023), 2023, Xi’an, China

Abstract

Accurate measurement of photosensitizer concentration in real-time in vivo bladder tissue was beneficial for improving the effectiveness of photodynamic therapy and achieving precise treatment of bladder tumor. In this paper, the potential ability of a transurethral photoacoustic imaging technique in visualizing and monitoring the photosensitizer concentration in the photodynamic therapy of bladder was evaluated. A bladder tissue optical model was established, and 3D Monte Carlo light transport method was coupled to calculate the photoacoustic signal. Photoacoustic signals in different photosensitizer concentrations were recorded. Results illustrated that a clear linearity between the photoacoustic signal intensity and photosensitizer concentration can be observed. It revealed that the proposed transurethral photoacoustic imaging technique has the potential to estimate in vivo photosensitizer concentrations and to guide laser-induced photodynamic therapy of bladder tumor.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Dongqing Peng, Qiuqin Su, and Haofang Yu "Photosensitizer concentration monitoring in photodynamic therapy of bladder by photoacoustic imaging technique", Proc. SPIE 12935, Fourteenth International Conference on Information Optics and Photonics (CIOP 2023), 129351J (24 November 2023); https://doi.org/10.1117/12.3006034

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